Reagent for quantitative determination of Fibrinogen in human plasma
The method uses Von Clauss and al. method.
In the presence of an excess of thrombin, the time of formation of the fibrin clot in the plasma (pre-diluted) is reversely proportional to the amount of fibrinogen in the sample. The clotting time is measured at 37°C.
Fibrinogen is a glycoprotein (340 KDa) synthesised by liver and present in the plasma at a level within 2 to 4 g/L.
The concentration of fibrinogen is increased in infections, estrogens ingestion, tissue necrosis, obesity, pregnancies and diabetes. An increase of fibrinogen is also involved as a risk factor for coronary artery disorders and cerebrovascular diseases.
A decrease of fibrinogen in plasma is associated with:
- liver diseases (cirrhosis, jaundice)
- Fibrinolysis or disseminated intravascular coagulation (DIC)
Presentation and Technical Data Sheet
|CODE||Presentation||Technical data sheet||MSDS|
|FI02||R1 : 5 x 2mL
R2 : 1 x 60mL (Dilution buffer)
|FI05||R1 : 10 x 5mL
R2 : 1 x 125mL (Dilution buffer)